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胞質(zhì)緊密粘連蛋白1/閉鎖小帶蛋白1抗體
  • 產(chǎn)品貨號(hào)：
    BN42195R
  • 中文名稱：
    胞質(zhì)緊密粘連蛋白1/閉鎖小帶蛋白1抗體
  • 英文名稱：
    Rabbit anti-ZO-1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN42195R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Pig(predicted:Mouse,Rat,Chicken,Dog,Cow,Rabbit,GuineaPig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN42195R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Pig(predicted:Mouse,Rat,Chicken,Dog,Cow,Rabbit,GuineaPig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN42195R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Pig(predicted:Mouse,Rat,Chicken,Dog,Cow,Rabbit,GuineaPig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱ZO-1
中文名稱胞質(zhì)緊密粘連蛋白1/閉鎖小帶蛋白1抗體
別    名ZO1 tight junction protein; Tight junction protein 1; Tight junction protein ZO-1; Tight junction protein ZO1; TJP1; zo-1; Zo1; ZO1_HUMAN; Zona occludens 1; Zona occludens 1 protein; Zona occludens protein 1; Zonula occludens 1 protein; Zonula occludens protein 1.  



研究領(lǐng)域細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞粘附分子  細(xì)胞表面分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Pig,  (predicted: Mouse, Rat, Chicken, Dog, Cow, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量191kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ZO-1:1551-1702/1733 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions.

Function:
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

Subunit:
Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with CDC42BPB and MYZAP. Interacts (via PDZ domain) with GJA1.

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells.

Tissue Specificity:
The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

Post-translational modifications:
Phosphorylated. Dephosphorylated by PTPRJ.

Similarity:
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.
Contains 1 ZU5 domain.

SWISS:
Q07157

Gene ID:
7082

Database links:

Entrez Gene: 7082 Human

Entrez Gene: 21872 Mouse

Omim: 601009 Human

SwissProt: Q07157 Human

SwissProt: P39447 Mouse

Unigene: 510833 Human

Unigene: 4342 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胞質(zhì)緊密粘連蛋白1（ZO-1）是多結(jié)構(gòu)域蛋白家族膜結(jié)合鳥苷酸激酶的家族成員，在緊密連接蛋白的組成成分中起到對(duì)組織分化和器官形成方面起較重要的作用。ZO-1在包括腎、胎盤、血腦屏障等許多組織都有不同的表達(dá)，可與緊密連接上的很多跨膜蛋白相互作用。也有學(xué)者認(rèn)為：ZO-1的改變與細(xì)胞通透性的增加有關(guān)。