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細胞色素cP450 CYP26A1重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42164R
  • 中文名稱：
    細胞色素cP450 CYP26A1重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-CYP26A1 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN42164R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

  • BN42164R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human(predicted:Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

產(chǎn)品描述

英文名稱CYP26A1
中文名稱細胞色素cP450 CYP26A1重組兔單克隆抗體
別    名CP26; CP26A_HUMAN; CYP26; CYP26A 1; cyp26a1; Cytochrome P450 26A1; Cytochrome P450 family 26 subfamily A polypeptide 1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; Cytochrome P450RAI; hP450RAI; OTTHUMP00000020102; OTTHUMP00000020103; P450; P450 retinoic acid inactivating 1; P450RAI; P450RAI1; Retinoic acid 4 hydroxylase; Retinoic acid 4-hydroxylase; Retinoic acid metabolizing cytochrome; Retinoic acid-metabolizing cytochrome.  
研究領(lǐng)域腫瘤  細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號11A1
交叉反應(yīng)Human,  (predicted: Rat, )
產(chǎn)品應(yīng)用WB=1:500-1000 ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human CYP26A1:200-400/497 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.

Function:
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Subcellular Location : Endoplasmic reticulum membrane. Microsome membrane.

Tissue Specificity:
Highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain.

Similarity:
Belongs to the cytochrome P450 family.

SWISS:
O43174

Gene ID:
1592

Database links:

Entrez Gene: 1592 Human

Entrez Gene: 154985 Rat

Omim: 602239 Human

SwissProt: O43174 Human

Unigene: 150595 Human

Unigene: 81072 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications