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HMGCR重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42145R
  • 中文名稱：
    HMGCR重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-HMGCR Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN42145R-50ul

    50ul

    ￥2020.00

    交叉反應：Human(predicted:Rat,Mouse) 推薦應用：WB,IP

  • BN42145R-100ul

    100ul

    ￥3240.00

    交叉反應：Human(predicted:Rat,Mouse) 推薦應用：WB,IP

產(chǎn)品描述

英文名稱HMGCR
中文名稱HMGCR重組兔單克隆抗體
別    名3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269.  
研究領域腫瘤  細胞生物  免疫學  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號7C5
交叉反應Human,  (predicted: Mouse, Rat, )
產(chǎn)品應用WB=1:1000-2000 IP=1:10-50 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量97kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HMGCR: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.

Subunit:
Homodimer.

Subcellular Location:
Endoplasmic reticulum membrane. Peroxisome membrane.

Similarity:
Belongs to the HMG-CoA reductase family.

SWISS:
P04035

Gene ID:
3156

Database links:

Entrez Gene: 3156 Human

Entrez Gene: 15357 Mouse

Entrez Gene: 25675 Rat

Omim: 142910 Human

SwissProt: P04035 Human

SwissProt: Q01237 Mouse

SwissProt: P51639 Rat

Unigene: 628096 Human

Unigene: 643495 Human

Unigene: 316652 Mouse

Unigene: 9437 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.












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