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重組兔血管緊張素轉換酶單克隆抗體
  • 產品貨號：
    BN42141R
  • 中文名稱：
    重組兔血管緊張素轉換酶單克隆抗體
  • 英文名稱：
    Rabbit anti-ACE2 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN42141R-50ul

    50ul

    ￥2020.00

    交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN42141R-100ul

    100ul

    ￥3240.00

    交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱ACE2
中文名稱重組兔血管緊張素轉換酶單克隆抗體
別    名ACE-2; ACE 2; Angiotensin converting enzyme 2; ACE related carboxypeptidase; ACEH; Angiotensin converting enzyme homolog; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin I converting enzyme 2; DKFZP434A014; EC 3.4.17; OTTHUMP00000022963; angiotensin-converting enzyme 2 precursor; ACE2_HUMAN; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2.  
研究領域細胞生物  免疫學  信號轉導  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號3F1
交叉反應Human, Mouse, Rat, 
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50 IF=1:100-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量92kDa
細胞定位細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ACE2:180-240/805 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產品介紹Angiotensin converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9], or the conversion of angiotensin II to angiotensin 1-7. ACE2 has direct effects on cardiac function,a and is expressed predominantly in vascular endothelial cells of the heart and the kidneys. ACE2 is not sensitive to the ACE inhibitor drugs used to treat hypertension.
ACE2 receptors have been shown to be the entry point into human cells for some coronaviruses, including the SARS virus[10]. A number of studies have identified that the entry point is the same for SARS-CoV-2, the COVID-19 virus.

Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Subunit:
Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.

Subcellular Location:
Processed angiotensin-converting enzyme 2: Secreted.
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

Post-translational modifications:
N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form.
Belongs to the peptidase M2 family.

Similarity:
Belongs to the peptidase M2 family.

SWISS:
Q9BYF1

Gene ID:
59272

Database links:

Entrez Gene: 59272 Human

Entrez Gene: 70008 Mouse

Entrez Gene: 302668 Rat

Omim: 300335 Human

SwissProt: Q9BYF1 Human

SwissProt: Q8R0I0 Mouse

SwissProt: Q5EGZ1 Rat

Unigene: 178098 Human

Unigene: 13451 Mouse

Unigene: 129779 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解（Synthesis and Degradation）
ACE-2的分布范圍比較局限，ACE2主要在心臟、腎臟、睪丸中表達顯著， 近來人們發(fā)現(xiàn)ACE2也分布在胃腸道、腦和肺臟中。
有關學者在研究心臟和腎臟中發(fā)現(xiàn)，ACE2在心肌缺血、腎功能衰竭、動脈粥樣硬化和糖尿病并發(fā)癥中，ACE2對血管緊張素產生和降解過程中有一定的生理作用。
特別是對ACE2在具有生理活性的-活性肽產生過程中的作用更值得進一步研究。 ACE2的發(fā)現(xiàn)為心血管病和腎臟病研究開辟了新天地，并提供了新的治療靶點，可能導致未來心血管疾病治療策略的改變。