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CD9重組兔單克隆抗體
  • 產品貨號：
    BN42118R
  • 中文名稱：
    CD9重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-CD9 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42118R-50ul

    50ul

    ￥2020.00

    交叉反應：Mouse,Human(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,ICC,ELISA

  • BN42118R-100ul

    100ul

    ￥3240.00

    交叉反應：Mouse,Human(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,ICC,ELISA

產品描述

英文名稱CD9
中文名稱CD9重組兔單克隆抗體
別    名Tetraspanin 29; 5H9; 5H9 antigen; Antigen defined by monoclonal; 602 29; Antigen defined by monoclonal; 60229; BA 2; BA2; BTCC 1; BTCC1; CD 9; CD9; CD9 antigen; CD9 antigen p24; CD9 molecule; CD9_HUMAN; Cell growth inhibiting gene 2 protein; Cell growth-inhibiting gene 2 protein; DRAP 27; DRAP27; GIG 2; GIG2; Growth inhibiting gene 2 protein; Leukocyte antigen MIC3; MIC 3; MIC3; Motility related protein; Motility-related protein; MRP 1; MRP-1; MRP1; p24; P24; p24 antigen; Tetraspanin 29; Tetraspanin-29; Tetraspanin29; Tspan 29; Tspan-29; Tspan29.  
研究領域腫瘤  細胞生物  免疫學  發(fā)育生物學  細胞表面分子  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號4C2
交叉反應Human, Mouse,  (predicted: Rat, )
產品應用WB=1:500-1000 ELISA=1:5000-10000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
細胞定位細胞膜 
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原Recombinant human CD9 : 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產品介紹CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. It belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). It also regulates cell motility in a variety of cell lines, and appears to be an important regulator of Schwann cell behaviour in peripheral nerve.

Function:
Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.

Subunit:
Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed by a variety of hematopoietic and epithelial cells.

Post-translational modifications:
Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

SWISS:
P21926

Gene ID:
928

Database links:

Entrez Gene: 928 Human

Entrez Gene: 12527 Mouse

Entrez Gene: 24936 Rat

Omim: 143030 Human

SwissProt: P21926 Human

SwissProt: P40240 Mouse

SwissProt: P40241 Rat

Unigene: 114286 Human

Unigene: 210676 Mouse

Unigene: 404614 Mouse

Unigene: 2091 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD9是一種普遍存在于細胞膜表面屬于四跨膜超蛋白家族的細胞表面糖蛋白, 參與質膜的融合過程，在細胞膜生物學中發(fā)揮重要作用。 近年來經(jīng)研究發(fā)現(xiàn)，CD9與多種腫瘤轉移有關，故稱腫瘤轉移抑制基因亦稱抗腫瘤轉移基因。是一個新的腫瘤轉移抑制基因膜運動相關蛋白-1(CD9/MRP-1)，其分子功能還有待于進一步研究。CD9主要在早B細胞、活化T淋巴細胞、嗜酸性粒細胞、嗜堿性粒細胞和血小板表達。