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沉默調(diào)節(jié)相關(guān)蛋白2重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42109R
  • 中文名稱：
    沉默調(diào)節(jié)相關(guān)蛋白2重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-SIRT2 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN42109R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42109R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱SIRT2
中文名稱沉默調(diào)節(jié)相關(guān)蛋白2重組兔單克隆抗體
別    名FLJ35621; FLJ37491; NAD dependent deacetylase sirtuin 2; NAD-dependent deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; SIR 2; SIR2; SIR2 like; SIR2 like protein 2; Sir2 related protein type 2; SIR2-like protein 2; SIR2L; SIR2L2; SIRT 2; SIRT2; SIRT2_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae); Sirtuin 2; Sirtuin type 2; Sirtuin2.  
研究領(lǐng)域細胞生物  信號轉(zhuǎn)導(dǎo)  細胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號4G12
交叉反應(yīng)Human, Rat,  (predicted: Mouse, )
產(chǎn)品應(yīng)用WB=1:200-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human SIRT2 protein, around C-terminal 150aa: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

Function:
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.

Subcellular Location:
Cytoplasm, cytoskeleton. Colocalizes with microtubules.

Tissue Specificity:
Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.

Post-translational modifications:
Phosphorylated at the G2/M transition of the cell cycle.

Similarity:
Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.

SWISS:
Q8IXJ6

Gene ID:
22933

Database links:

Entrez Gene: 22933 Human

Omim: 604480 Human

SwissProt: Q8IXJ6 Human

Unigene: 466693 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.