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異染色質蛋白1-γ/HP-1γ單克隆抗體
  • 產品貨號：
    BN42046M
  • 中文名稱：
    異染色質蛋白1-γ/HP-1γ單克隆抗體
  • 英文名稱：
    Mouse anti-HP1 gamma Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN42046M-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN42046M-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱HP1 gamma
中文名稱異染色質蛋白1-γ/HP-1γ單克隆抗體
別    名CBX 3; CBX3; Chromobox homolog 3; Chromobox protein homolog 3; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma; HP1 gamma homolog; HP1Hs gamma ; Modifier 2; protein HP1-GAMMA; HP1g; M32; MGC118084; CBX3_HUMAN; Modifier 2 protein;   
研究領域腫瘤  細胞生物  染色質和核信號  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號5B9
交叉反應Human, Mouse, Rat, 
產品應用ELISA=1:1000-5000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human HP1 gamma Protein: 
亞    型IgG
純化方法affinity purified by Protein G
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Function:
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Subunit:
Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 and SP100. Interacts with TIF1A. Interacts with MIS12 and DSN1. Can interact directly with CBX5 via the chromoshadow domain. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1.

Subcellular Location:
Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential).

Post-translational modifications:
Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.

Similarity:
Contains 2 chromo domains.

SWISS:
Q13185

Gene ID:
11335

Database links:

Entrez Gene: 11335 Human

Entrez Gene: 12417 Mouse

Entrez Gene: 297093 Rat

Omim: 604477 Human

SwissProt: Q13185 Human

SwissProt: P23198 Mouse

Unigene: 381189 Human

Unigene: 280968 Mouse

Unigene: 458234 Mouse

Unigene: 485141 Mouse




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.