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蛋白質(zhì)酪氨酸激酶JAK-1單克隆抗體
  • 產(chǎn)品貨號：
    BN42031M
  • 中文名稱：
    蛋白質(zhì)酪氨酸激酶JAK-1單克隆抗體
  • 英文名稱：
    Mouse anti-JAK1 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN42031M-50ul

    50ul

    ￥1486.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：IHC-P,IHC-F,ICC,IF

  • BN42031M-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱JAK1
中文名稱蛋白質(zhì)酪氨酸激酶JAK-1單克隆抗體
別    名JAK 1; JAK 1A; JAK 1B; JAK1; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; JAK1_HUMAN.   
研究領域腫瘤  細胞生物  免疫學  信號轉導  激酶和磷酸酶  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號9G7
交叉反應Human,  (predicted: Mouse, Rat, )
產(chǎn)品應用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量133kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human JAK1: 
亞    型IgG
純化方法affinity purified by Protein G
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Function:
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Subunit:
Interacts with FER (By similarity). Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB.

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Tissue Specificity:
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 2 protein kinase domains.
Contains 1 SH2 domain.

SWISS:
P23458

Gene ID:
3716

Database links:

Entrez Gene: 395681 Chicken

Entrez Gene: 3716 Human

Entrez Gene: 16451 Mouse

Entrez Gene: 397202 Pig

Entrez Gene: 84598 Rat

Omim: 147795 Human

SwissProt: P23458 Human

SwissProt: P52332 Mouse

Unigene: 207538 Human

Unigene: 289657 Mouse

Unigene: 90191 Rat 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

激酶和磷酸酶（Kinases and Phosphatases）