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波形蛋白單克隆抗體
  • 產(chǎn)品貨號：
    BN42003M
  • 中文名稱：
    波形蛋白單克隆抗體
  • 英文名稱：
    Mouse anti-Vimentin Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42003M-50ul

    50ul

    ￥1486.00

    交叉反應：Human(predicted:Rat,Mouse) 推薦應用：WB,IHC-P,ICC,Flow-Cyt

  • BN42003M-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Rat,Mouse) 推薦應用：WB,IHC-P,ICC,Flow-Cyt

產(chǎn)品描述

英文名稱Vimentin
中文名稱波形蛋白單克隆抗體
別    名FLJ36605; OTTHUMP00000019224; VIM; VIME_HUMAN; Vimentin.  
研究領域腫瘤  細胞生物  發(fā)育生物學  信號轉導  干細胞  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號3B7
交叉反應Human,  (predicted: Mouse, Rat, )
產(chǎn)品應用WB=1:500-1000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
細胞定位細胞漿 細胞外基質 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Vimentin Protein: 
亞    型IgG
純化方法affinity purified by Protein G
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]

Function:
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.

Subunit:
Homopolymer assembled from elementary dimers. Interacts with HCV core protein. Interacts with LGSN and SYNM. Interacts (via rod region) with PLEC (via CH 1 domain) (By similarity). Interacts with SLC6A4. Interacts with STK33. Interacts with LARP6. Interacts with RAB8B (By similarity).

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.

Post-translational modifications:
Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin. One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P08670

Gene ID:
7431

Database links:

Entrez Gene: 7431 Human

Entrez Gene: 22352 Mouse

Entrez Gene: 81818 Rat

Omim: 193060 Human

SwissProt: P08670 Human

SwissProt: P20152 Mouse

SwissProt: P31000 Rat

Unigene: 455493 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Vimentin—波形蛋白。是五種主要的中間絲之一，存在于各種正常和病理性間質來源的組織，如纖維母細胞、內(nèi)皮細胞、淋巴細胞等正常細胞和肉瘤、淋巴瘤、黑色素瘤等腫瘤。波形蛋白是負責維持細胞骨架完整性的蛋白之一。