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熱休克蛋白90β/HSP90 β 單克隆抗體
  • 產(chǎn)品貨號：
    BN42001M
  • 中文名稱：
    熱休克蛋白90β/HSP90 β 單克隆抗體
  • 英文名稱：
    Mouse anti-HSP90 beta Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN42001M-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB

  • BN42001M-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB

產(chǎn)品描述

英文名稱HSP90 beta
中文名稱熱休克蛋白90β/HSP90 β 單克隆抗體
別    名HSP90 beta; D6S182; FLJ26984; Heat shock 90kD protein 1, beta; Heat shock protein 90kDa alpha (cytosolic) class B member 1; Heat shock protein beta; Heat shock protein HSP 90 beta; HSP 84; HSP84; HSP 90; HSP-90 BETA; HSP90B; HSPC2; HSPCB; HS90B_HUMAN; Heat shock protein HSP 90-beta; Heat shock 84 kDa.  
研究領域腫瘤  免疫學  信號轉(zhuǎn)導  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號2A2
交叉反應Human, Mouse, Rat, 
產(chǎn)品應用WB=1:500-1000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量84kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HSP90 beta: 
亞    型IgG
純化方法affinity purified by Protein G
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012].

Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Subunit:
Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4.

Subcellular Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Post-translational modifications:
Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
ISGylated.
S-nitrosylated; negatively regulates the ATPase activity (Probable).

Similarity:
Belongs to the heat shock protein 90 family.

SWISS:
P08238

Gene ID:
3326

Database links:

Entrez Gene: 3326 Human

Entrez Gene: 15516 Mouse

Entrez Gene: 301252 Rat

Omim: 140572 Human

SwissProt: P08238 Human

SwissProt: P11499 Mouse

SwissProt: P34058 Rat

Unigene: 509736 Human

Unigene: 2180 Mouse

Unigene: 98667 Rat 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HSP是細胞受應激原刺激后誘導產(chǎn)生的一組應激蛋白，與腫瘤發(fā)生、增殖及分化有關，HSP90β能夠抑制細胞凋亡與分化。