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神經(jīng)元特異性烯醇化酶單克隆抗體
  • 產(chǎn)品貨號：
    BN41993M
  • 中文名稱：
    神經(jīng)元特異性烯醇化酶單克隆抗體
  • 英文名稱：
    Mouse anti-NSE Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41993M-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P

  • BN41993M-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P

產(chǎn)品描述

英文名稱NSE
中文名稱神經(jīng)元特異性烯醇化酶單克隆抗體
別    名Gamma-enolase; Gamma enolase; Neural enolase; Neuron specific enolase; neurone-specific enolase; 2 phospho D glycerate hydrolyase; Eno 2; Eno2; ENO2; ENOG; Enolase 2; Enolase 2 gamma neuronal; Enolase2; Neuron specific enolase; Neuron specific gamma enolase; NSE; ENOG_HUMAN; Gamma-enolase; 2-phospho-D-glycerate hydro-lyase; enolase 2, gamma, neuronal.  



研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號15E2
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human NSE protein: 
亞    型IgG
純化方法affinity purified by Protein G
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008].

Function:
Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.

Subunit:
Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.

Subcellular Location:
Cytoplasm. Cell membrane. Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.

Tissue Specificity:
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Similarity:
Belongs to the enolase family.

SWISS:
P09104

Gene ID:
2026

Database links:

Entrez Gene: 2026 Human

Entrez Gene: 13807 Mouse

Entrez Gene: 24334 Rat

Omim: 131360 Human

SwissProt: P09104 Human

SwissProt: P17183 Mouse

SwissProt: P07323 Rat

Unigene: 511915 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)元特異性烯醇化酶（NSE）存在于神經(jīng)元細(xì)胞和神經(jīng)內(nèi)分泌組織中，起源于神經(jīng)內(nèi)分泌細(xì)胞的腫瘤可產(chǎn)生過量的NSE。NSE也是小細(xì)胞肺癌的檢測指標(biāo)，70％左右的小細(xì)胞肺癌患者血中NSE升高，而其他組織型肺癌NSE升高的患者僅為10％～20％。