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細(xì)胞間粘附分子-1單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN41973M
  • 中文名稱：
    細(xì)胞間粘附分子-1單克隆抗體
  • 英文名稱：
    Mouse anti-ICAM1/CD54 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN41973M-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41973M-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱ICAM1/CD54
中文名稱細(xì)胞間粘附分子-1單克隆抗體
別    名BB2; CD54 antigen; CD54; ICAM1; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; major group rhinovirus receptor.  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞粘附分子  細(xì)胞表面分子  糖蛋白  
抗體來(lái)源Mouse
克隆類型Monoclonal
克 隆 號(hào)4E5
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human ICAM1/CD54:321-420/532 
亞    型IgG
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008].

Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Subunit:
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Post-translational modifications:
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Similarity:
Belongs to the immunoglobulin superfamily. ICAM family.
ontains 5 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
P05362

Gene ID:
3383

Database links:

Entrez Gene: 3383 Human

Entrez Gene: 15894 Mouse

Entrez Gene: 25464 Rat

Omim: 147840 Human

Unigene: 643447 Human

SwissProt: P05362 Human

SwissProt: P13597 Mouse

SwissProt: Q00238 Rat

Unigene: 435508 Mouse

Unigene: 12 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.