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CD81抗體
  • 產(chǎn)品貨號(hào)：
    BN41954R
  • 中文名稱(chēng)：
    CD81抗體
  • 英文名稱(chēng)：
    Rabbit anti-CD81 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41954R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Mouse,Human(predicted:Sheep,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IF,Flow-Cyt,ELISA

  • BN41954R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Human(predicted:Sheep,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IF,Flow-Cyt,ELISA

  • BN41954R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Human(predicted:Sheep,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)CD81
中文名稱(chēng)CD81抗體
別    名26 kDa cell surface protein TAPA 1; 26 kDa cell surface protein TAPA-1; 26 kDa cell surface protein TAPA1; CD 81; CD81; CD81 antigen; CD81 molecule; CD81_HUMAN; CVID6; S5.7; TAPA 1; Target of the antiproliferative antibody 1; Tetraspanin 28; Tetraspanin-28; Tetraspanin28; Tspan 28; Tspan-28; Tspan28.  



研究領(lǐng)域細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)菌及病毒  淋巴細(xì)胞  b-淋巴細(xì)胞  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量26kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TAPA1/CD81:101-210/236 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008].

Function:
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May acts a the viral receptor for HCV.

Subunit:
Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. Interacts directly with IGSF8. Interacts with CD53 and SCIMP.

Subcellular Location:
Membrane.

Tissue Specificity:
Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.

DISEASE:
Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6); also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

SWISS:
P60033

Gene ID:
975

Database links:

Entrez Gene: 975 Human

Omim: 186845 Human

SwissProt: P60033 Human

Unigene: 54457 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.