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巢蛋白1抗體
  • 產(chǎn)品貨號：
    BN41953R
  • 中文名稱：
    巢蛋白1抗體
  • 英文名稱：
    Rabbit anti-Nidogen Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41953R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse(predicted:Rabbit,Cow,Human) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41953R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse(predicted:Rabbit,Cow,Human) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41953R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse(predicted:Rabbit,Cow,Human) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Nidogen
中文名稱巢蛋白1抗體
別    名Ent; Entactin 1; Entactin; NID 1; NID; NID-1; Nid1; Nidogen (enactin); Nidogen 1; Nidogen; Nidogen-1; NID1_HUMAN.  
研究領(lǐng)域細胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細胞周期蛋白  細胞粘附分子  細胞分化  細胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Cow, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量133kDa
細胞定位細胞膜 細胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Entactin:1001-1100/1247 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Basement membranes are the earliest extracellular matrices produced during embryogenesis. They are synthesized and incorporated into the supramolecular architecture of several components, including laminins, Collagen IV, Nidogen and proteoglycans. Nidogen/Entactin, a sulfated glycoprotein, acts as a link between the extracellular matrix molecules Laminin 1 and Collagen Type IV, and thereby participates in the assembly of basement membranes. Nidogen is a highly conserved member of the Nidogen family, which also includes Nidogen-2. Nidogen-2 has a high level of N- and O-glycosylation, and it interacts with Collagens Type I and IV and Perlecan at a comparable level to Nidogen. Nidogen is synthesized and secreted in primary and established mesenchymal peritubular cells and myoepithelial cells, and it affects adhesion of peritubular cells in an autocrine manner. Nidogen is expressed during embryonic and fetal development exclusively in fully developed basement membranes of the ectoderm and is not expressed in the developing endodermal basement membrane or in membranes disrupted during mesoderm formation. Nidogen also cooperates with Laminin 1 to regulate b-casein expression.

Function:
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

Subunit:
Interacts with FBLN1 and LGALS3BP. Interacts with PLXDC1.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.

Post-translational modifications:
N- and O-glycosylated.

Similarity:
Contains 6 EGF-like domains.
Contains 1 NIDO domain.
Contains 1 nidogen G2 beta-barrel domain.
Contains 1 thyroglobulin type-1 domain.

SWISS:
P14543

Gene ID:
4811

Database links:

Entrez Gene: 534319 Cow

Entrez Gene: 4811 Human

Entrez Gene: 18073 Mouse

Entrez Gene: 25494 Rat

Omim: 131390 Human

SwissProt: P14543 Human

SwissProt: P10493 Mouse

SwissProt: P08460 Rat

Unigene: 356624 Human

Unigene: 4691 Mouse

Unigene: 105658 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications