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信號(hào)通路Wnt4抗體
  • 產(chǎn)品貨號(hào)：
    BN41935R
  • 中文名稱：
    信號(hào)通路Wnt4抗體
  • 英文名稱：
    Rabbit anti-WNT4 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41935R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41935R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41935R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱WNT4
中文名稱信號(hào)通路Wnt4抗體
別    名WNT4_HUMAN; Protein Wnt-4.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
細(xì)胞定位細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human WNT4:201-300/351 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.

Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.

Subunit:
Interacts with PORCN.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

DISEASE:
Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]; also called Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls.
Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]; also known as SERKAL syndrome.
Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL) [MIM:158330].

Similarity:
Belongs to the Wnt family.

SWISS:
P56705

Gene ID:
54361

Database links:

Entrez Gene: 54361 Human

Entrez Gene: 22417 Mouse

Omim: 603490 Human

SwissProt: P56705 Human

SwissProt: P22724 Mouse

Unigene: 25766 Human

Unigene: 611722 Human

Unigene: 20355 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications