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硫氧還蛋白結(jié)合蛋白2抗體
  • 產(chǎn)品貨號：
    BN41882R
  • 中文名稱：
    硫氧還蛋白結(jié)合蛋白2抗體
  • 英文名稱：
    Rabbit anti-TXNIP Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41882R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Pig,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41882R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Pig,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41882R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Pig,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱TXNIP
中文名稱硫氧還蛋白結(jié)合蛋白2抗體
別    名;THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; Vitamin D3 up-regulated protein 1; TXNIP_HUMAN. 


研究領(lǐng)域腫瘤  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Dog, Pig, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TXNIP:101-200/391 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt).

Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Subunit:
Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.

Subcellular Location:
Cytoplasm

Post-translational modifications:
Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

Similarity:
Belongs to the arrestin family.

SWISS:
Q9H3M7

Gene ID:
10628

Database links:
UniProtKB/Swiss-Prot: Q9H3M7.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    硫氧還蛋白結(jié)合蛋白-2 (TRX-binding protein-2，TBP-2)又稱:維生素D3上調(diào)蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或稱硫氧還蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。
    TBP-2與硫氧還蛋白(thioredoxin，TRX)的活性部位結(jié)合，抑制其活性，除了參與多種氧化應(yīng)激反應(yīng)，還具有多種生物學功能。
    有學者認為：TBP-2與腫瘤密切相關(guān)，有些腫瘤組織中，TBP-2表達降低或缺失。TBP-2表達增高時，細胞周期停滯，腫瘤細胞繁殖受到抑制。目前已成為腫瘤研究的重要靶點。



















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