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肌原調(diào)節(jié)蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41822R
  • 中文名稱：
    肌原調(diào)節(jié)蛋白抗體
  • 英文名稱：
    Rabbit anti-MyoD1/Myf3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

    產(chǎn)品規(guī)格

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  • BN41822R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN41822R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN41822R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱MyoD1/Myf3
中文名稱肌原調(diào)節(jié)蛋白抗體
別    名Myogenic differentiation 1; AI503393; bHLHc1; MD1; MGC156574; MYF3; MYOD; MYOD1; PUM; MYOD1_HUMAN; Class C basic helix-loop-helix protein 1; bHLHc1; Myogenic factor 3; Myf-3


研究領(lǐng)域免疫學(xué)  發(fā)育生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse MyoD1:51-150/318 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]

Function:
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.
Ubiquitinated on the N-terminus; which is required for proteasomal degradation

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

SWISS:
P10085

Gene ID:
17927

Database links:

Entrez Gene: 374048 Chicken

Entrez Gene: 281938 Cow

Entrez Gene: 4654 Human

Entrez Gene: 17927 Mouse

Entrez Gene: 407604 Pig

Entrez Gene: 337868 Rat

Entrez Gene: 443405 Sheep

Omim: 159970 Human

SwissProt: P16075 Chicken

SwissProt: Q7YS82 Cow

SwissProt: P15172 Human

SwissProt: P10085 Mouse

SwissProt: P49811 Pig

SwissProt: Q02346 Rat

SwissProt: P29331 Sheep

Unigene: 181768 Human

Unigene: 1526 Mouse

Unigene: 9493 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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