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周斑蛋白抗體
  • 產品貨號：
    BN41800R
  • 中文名稱：
    周斑蛋白抗體
  • 英文名稱：
    Rabbit anti-Periplakin Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN41800R-50ul

    50ul

    ￥1486.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB

  • BN41800R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB

  • BN41800R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB

產品描述

英文名稱Periplakin
中文名稱周斑蛋白抗體
別    名190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor; 195 kDa cornified envelope precursor protein; AW553870; KIAA0568; MGC134872; PEPL_HUMAN; Periplakin; ppl.  
研究領域腫瘤  細胞生物  信號轉導  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, )
產品應用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量205kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Periplakin:1-100/1756 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq, Jul 2008]

Function:
Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling.

Subcellular Location:
Cell junction > desmosome. Cytoplasm > cytoskeleton. Cell membrane. Nucleus. Mitochondrion. Associated with desmosomes and intermediate filaments.

Tissue Specificity:
Expressed in stratified squamous epithelia and in some other epithelia.

Similarity:
Belongs to the plakin or cytolinker family.
Contains 2 plectin repeats.
Contains 4 spectrin repeats.

SWISS:
O60437

Gene ID:
5493

Database links:

Entrez Gene: 5493 Human

Entrez Gene: 19041 Mouse

Entrez Gene: 302934 Rat

Omim: 602871 Human

SwissProt: O60437 Human

SwissProt: Q9R269 Mouse

Unigene: 192233 Human

Unigene: 266875 Mouse

Unigene: 25259 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications