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血管緊張素Ⅱ1A型受體抗體
  • 產(chǎn)品貨號(hào)：
    BN41784R
  • 中文名稱：
    血管緊張素Ⅱ1A型受體抗體
  • 英文名稱：
    Rabbit anti-Angiotensin II type 1A receptor Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41784R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF

  • BN41784R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF

  • BN41784R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF

產(chǎn)品描述

英文名稱Angiotensin II type 1A receptor
中文名稱血管緊張素Ⅱ1A型受體抗體
別    名AGTR1; Agtr1a; AT1; AT1A; AT1AR; Type 1 angiotensin II receptor; AGTR1_HUMAN; AGTR1B; AT2R1; AT2R1B. 


研究領(lǐng)域心血管  細(xì)胞生物  免疫學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from the middle of human Angiotensin II type 1A receptor:101-200/359 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The Angiotensin II type 1 receptor (AT1) is the primary effector of Angiotensin II, a key regulator of blood pressure and fluid homeostasis. It is involved in pathogenesis of several cardiovascular diseases such as hypertension, cardiac hypertrophy and congestive heart failure. Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). AT1 has three isoforms in rodents: AT1A (359 aa), AT1B (359 aa), and AT1C (177 aa). Rat AT1's are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular, while the C-terminus is predicted to be cytoplasmic. AT1's are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle.

Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit:
Interacts with MAS1 (Probable). Interacts with ARRB1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Liver, lung, adrenal and adrenocortical adenomas.

Post-translational modifications:
C-terminal Ser or Thr residues may be phosphorylated.

DISEASE:
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P30556

Gene ID:
185

Database links:

Entrez Gene: 185 Human

Entrez Gene: 24180 Rat

Entrez Gene: 81638 Rat

Omim: 106165 Human

SwissProt: P30556 Human

SwissProt: P34976 Rabbit

SwissProt: P25095 Rat

SwissProt: P29089 Rat

Unigene: 477887 Human

Unigene: 728754 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.