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血紅素氧合酶 1/熱休克蛋白32抗體
  • 產品貨號：
    BN41776R
  • 中文名稱：
    血紅素氧合酶 1/熱休克蛋白32抗體
  • 英文名稱：
    Rabbit anti-Heme Oxygenase 1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41776R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat,Pig(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41776R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat,Pig(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41776R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat,Pig(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱Heme Oxygenase 1
中文名稱血紅素氧合酶 1/熱休克蛋白32抗體
別    名Heme oxygenase (decycling) 1; Heme oxygenase 1; Hemox; HMOX 1; Hmox; HMOX1; HO 1; HO-1; HO; HO1; Hsp32; bK286B10; D8Wsu38e; HMOX1_HUMAN.  
研究領域腫瘤  心血管  免疫學  神經生物學  信號轉導  表觀遺傳學  Alzheimer's  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, Pig,  (predicted: Chicken, Dog, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HO-1:101-200/288 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹The hemeoxygenase-1 calls that the hemoglobin oxidizes to synthesize the enzyme again-1( hemeoxygenase-1, HO-1) is the catalyst enzyme that a kind of hemoglobin declines the solution, under the NADPH and the cell dye P-450 revivification enzymes and the member oxygen functions, the catalyst HO-1 hemoglobin declines the solution as the courage green vegetable, CO and irons, the former revivification has the very strong anti- to oxidize the ability after become the red vegetable of courage , the latter is a kind of important letter to make the member.

Function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.

Subcellular Location:
Microsome. Endoplasmic reticulum.

Tissue Specificity:
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).

DISEASE:
Defects in HMOX1 are the cause of heme oxygenase 1 deficiency (HMOX1D) [MIM:614034]. A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.

Similarity:
Belongs to the heme oxygenase family.

SWISS:
P09601

Gene ID:
3162

Database links:

Entrez Gene: 442987 Dog

Entrez Gene: 3162 Human

Entrez Gene: 15368 Mouse

Entrez Gene: 24451 Rat

Omim: 141250 Human

SwissProt: Q5E9F2 Cow

SwissProt: P09601 Human

SwissProt: P14901 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.