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凝集素樣氧化型低密度脂蛋白受體抗體
  • 產(chǎn)品貨號：
    BN41773R
  • 中文名稱：
    凝集素樣氧化型低密度脂蛋白受體抗體
  • 英文名稱：
    Rabbit anti-LOX 1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41773R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Rat,Rabbit(predicted:Mouse,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41773R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Rat,Rabbit(predicted:Mouse,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41773R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Rat,Rabbit(predicted:Mouse,Cow) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱LOX 1
中文名稱凝集素樣氧化型低密度脂蛋白受體抗體
別    名Lectin-type oxidized LDL receptor 1; OLR1; lectin-like low density lipoprotein receptor-1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; LOX-1; BLOX1; Contains: Oxidized low-density lipoprotein receptor 1, soluble form A; Oxidized low-density lipoprotein receptor 1, soluble form B; OLR1_HUMAN.  



研究領域心血管  免疫學  信號轉(zhuǎn)導  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat, Rabbit,  (predicted: Mouse, Cow, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量31/50kDa
細胞定位細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from rabbit LOX-1:201-273/273 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Function:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Subunit:
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.

Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists.

Tissue Specificity:
Highly expressed in endothelial cells, aortic intima and lung. Expressed at low level in other tissues.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 1 C-type lectin domain.

SWISS:
Q9XTA8

Gene ID:
100009322

Database links:

Entrez Gene: 4973 Human

Entrez Gene: 108078 Mouse

Entrez Gene: 140914 Rat

Omim: 602601 Human

SwissProt: P78380 Human

SwissProt: Q9EQ09 Mouse

SwissProt: Q9XTA8 Rabbit

SwissProt: O70156 Rat

Unigene: 412484 Human

Unigene: 293626 Mouse

Unigene: 87449 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

LOX-1(Lectin-like Ox-LDL receptor 1)即氧化低密度脂蛋白的內(nèi)皮受體，是清除受體或稱清道夫受體（Scavenger Receptor,SR）家族的一種，LOX-1作為氧化低密度脂蛋白的天然配體，與脂質(zhì)代謝有關。