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線(xiàn)粒體脫偶連蛋白2抗體

產(chǎn)品貨號(hào)：

BN41760R
中文名稱(chēng)：

線(xiàn)粒體脫偶連蛋白2抗體
英文名稱(chēng)：

Rabbit anti-UCP-2 Polyclonal antibody
品牌：

Biorigin

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產(chǎn)品規(guī)格

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BN41760R-50ul

50ul

￥1486.00

交叉反應(yīng)：Human,Mouse,Rat(predicted:Pig,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41760R-100ul

100ul

￥2360.00

交叉反應(yīng)：Human,Mouse,Rat(predicted:Pig,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN41760R-200ul

200ul

￥3490.00

交叉反應(yīng)：Human,Mouse,Rat(predicted:Pig,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)	UCP-2
中文名稱(chēng)	線(xiàn)粒體脫偶連蛋白2抗體
別名	Uncoupling Protein-2; UCP2; UCP 2; BMIQ4; Mitochondrial uncoupling protein 2; SLC25A8; UCPH; Uncoupling protein 2; Uncoupling protein 2 mitochondrial proton carrier; Solute carrier family 25 member 8; UCP2_MOUSE.

研究領(lǐng)域	細(xì)胞生物免疫學(xué) 染色質(zhì)和核信號(hào) 糖尿病
抗體來(lái)源	Rabbit
克隆類(lèi)型	Polyclonal
交叉反應(yīng)	Human, Mouse, Rat, (predicted: Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	34kDa
細(xì)胞定位	細(xì)胞漿
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from mouse UCP-2:201-309/309
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes. Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Subunit: Acts as a dimer forming a proton channel (By similarity). Subcellular Location: Mitochondrion inner membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle. Similarity: Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats. SWISS: P70406 Gene ID: 7351 Database links: Entrez Gene: 7351 Human Entrez Gene: 54315 Rat Omim: 601693 Human SwissProt: P55851 Human SwissProt: P56500 Rat Unigene: 80658 Human Unigene: 13333 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. UCP-2又稱(chēng)解耦聯(lián)蛋白 2 (UCP2 )是 1997年發(fā)現(xiàn)的一種新的解偶聯(lián)蛋白 ,它是線(xiàn)粒體內(nèi)膜載體家族的一員。與其類(lèi)似物UCP1相比 ,UCP2在棕色脂肪組織中含量較低 ,但在體內(nèi)分布廣泛。解耦聯(lián)蛋白(UCP)具有使線(xiàn)粒體呼吸鏈解耦聯(lián)作用,解耦聯(lián)所釋放的能量以熱能的形式散發(fā)。在對(duì)UCP與產(chǎn)熱關(guān)系的研究中,發(fā)現(xiàn)UCP2具有調(diào)節(jié)機(jī)體能量代謝的功能,并且可能是肥胖與2型糖尿病相關(guān)聯(lián)的一個(gè)重要基因。