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多巴胺受體D3抗體
  • 產(chǎn)品貨號：
    BN41747R
  • 中文名稱：
    多巴胺受體D3抗體
  • 英文名稱：
    Rabbit anti-Dopamine D3 receptor Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41747R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41747R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41747R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Dopamine D3 receptor
中文名稱多巴胺受體D3抗體
別    名DRD3; 3dopamine receptor; D; Dopamine receptor D3; DRD3; Dopamine receptor 3; ETM1; FET1; D(3) dopamine receptor; DRD3; DRD3_HUMAN.  
研究領(lǐng)域細胞生物  神經(jīng)生物學(xué)  細胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse DRD3:352-446/446 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is expressed in phylogenetically older regions of the brain, suggesting that it plays a role in cognitive and emotional functions. It is a target for drugs which treat schizophrenia, drug addiction, and Parkinson disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). Also known as: dopamine D3 receptor; 3 dopamine receptor; D; Dopamine receptor D3; DRD; ETM1; FET1.

Subunit:
Interacts with CLIC6. Interacts with GRK4. Interacts with PALM.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.

Tissue Specificity:
Brain.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P30728

Gene ID:
13490

Database links:

Entrez Gene: 1814 Human

Entrez Gene: 13490 Mouse

Entrez Gene: 29238 Rat

Omim: 126451 Human

SwissProt: P35462 Human

SwissProt: P30728 Mouse

SwissProt: P19020 Rat

Unigene: 121478 Human

Unigene: 439735 Mouse

Unigene: 10356 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

多巴胺受體D3常與某些精神、神經(jīng)疾病有關(guān)，如精神分裂癥、早發(fā)性癡呆等。但最新研究表明多巴胺受體與腫瘤細胞多藥耐藥有關(guān)。