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趨化因子受體1抗體
  • 產(chǎn)品貨號(hào)：
    BN41744R
  • 中文名稱：
    趨化因子受體1抗體
  • 英文名稱：
    Rabbit anti-CX3CR1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41744R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA

  • BN41744R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA

  • BN41744R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱CX3CR1
中文名稱趨化因子受體1抗體
別    名Beta chemokine receptor-like 1; C X3 C CKR 1; CCRL1; Chemokine C X3 C motif receptor 1; CMK BRL 1; CMKBLR1; CMK-BRL-1; CMKDR1; CX3C chemokine receptor 1; CX3C CKR1; Fractalkine Receptor; GPR13; GPRV28; V28; Chemokine receptor 1(chemokine (C-X3-C motif) receptor 1; C-X3-C CKR-1; CX3C1_HUMAN; CX3CR1; G-protein coupled receptor 13.  



研究領(lǐng)域腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  細(xì)胞粘附分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CX3CR1:151-250/355 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Function:
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.

Subunit:
Interacts with human respiratory syncytial virus (HRSV) protein G; this interaction modulates host immune response. Interacts with HIV-1 envelope polyprotein gp160.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in lymphoid and neural tissues.

DISEASE:
Age-related macular degeneration 12 (ARMD12) [MIM:613784]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P49238

Gene ID:
1524

Database links:

Entrez Gene: 1524 Human

Entrez Gene: 13051 Mouse

Entrez Gene: 171056 Rat

Omim: 601470 Human

SwissProt: P49238 Human

SwissProt: Q9Z0D9 Mouse

SwissProt: P35411 Rat

Unigene: 78913 Human

Unigene: 44065 Mouse

Unigene: 10482 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications