最近搜索：細胞培養(yǎng) 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>腫瘤細胞調(diào)亡素/死亡受體5抗體
腫瘤細胞調(diào)亡素/死亡受體5抗體
  • 產(chǎn)品貨號：
    BN41742R
  • 中文名稱：
    腫瘤細胞調(diào)亡素/死亡受體5抗體
  • 英文名稱：
    Rabbit anti-DR5 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41742R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41742R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41742R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱DR5
中文名稱腫瘤細胞調(diào)亡素/死亡受體5抗體
別    名sTRAIL Receptor 2; Death receptor 5; CD 262; CD262; CD262 antigen; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; p53 regulated DNA damage inducible cell death receptor (killer); TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; ZTNFR9. 





研究領(lǐng)域腫瘤  免疫學  細胞凋亡  細胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from rat DR5:301-381/381 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Subcellular Location:
Cell Membrane

Tissue Specificity:
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

DISEASE:
Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.

SWISS:
O14763

Gene ID:
364420

Database links:

Entrez Gene: 8795 Human

Entrez Gene: 21933 Mouse

Entrez Gene: 364420 Rat

Omim: 603612 Human

SwissProt: O14763 Human

SwissProt: Q9QZM4 Mouse

Unigene: 521456 Human

Unigene: 193430 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DR5分布比較廣泛，包括肝、脾、肺、胸腺和活化T細胞以及一些腫瘤細胞系。APO-2L在誘導轉(zhuǎn)化細胞和腫瘤細胞的調(diào)亡中，廣泛且迅速，多表達與胞漿。