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抑制素/腫瘤抑制因子抗體
  • 產(chǎn)品貨號(hào)：
    BN41716R
  • 中文名稱：
    抑制素/腫瘤抑制因子抗體
  • 英文名稱：
    Rabbit anti-Prohibitin Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41716R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41716R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41716R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Prohibitin
中文名稱阻抑素/腫瘤抑制因子抗體
別    名Mitochondrial Marker; PHB; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  細(xì)胞凋亡  細(xì)胞類型標(biāo)志物  線粒體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
細(xì)胞定位細(xì)胞漿 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Prohibitin:171-272/272 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Function:
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Subunit:
Interacts with PHB2. Interacts with STOML2.

Subcellular Location:
Mitochondrion inner membrane.

Tissue Specificity:
Widely expressed in different tissues.

Similarity:
Belongs to the prohibitin family.

SWISS:
P35232

Gene ID:
5245

Database links:

Entrez Gene: 5245 Human

Entrez Gene: 18673 Mouse

Entrez Gene: 25344 Rat

Omim: 176705 Human

SwissProt: P35232 Human

SwissProt: P67778 Mouse

SwissProt: P67779 Rat

Unigene: 514303 Human

Unigene: 263862 Mouse

Unigene: 29754 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Prohibitin(phb)基因是一種有效的腫瘤抑制基因，廣泛分布于不同種屬的各種生物細(xì)胞中，它所編碼的產(chǎn)物Prohibitin(PHB)蛋白結(jié)構(gòu)保守，既存在于線粒體內(nèi)膜上，發(fā)揮分子伴侶作用，也存在于細(xì)胞核內(nèi)，具有負(fù)性轉(zhuǎn)錄調(diào)控作用，因而對(duì)細(xì)胞代謝、生長(zhǎng)、分化、衰老以及凋亡等諸多方面發(fā)揮 著重要的調(diào)控作用，可能與某些腫瘤和退行性疾病的發(fā)生有關(guān)。