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腫瘤轉(zhuǎn)移相關(guān)蛋白1抗體
  • 產(chǎn)品貨號：
    BN41708R
  • 中文名稱：
    腫瘤轉(zhuǎn)移相關(guān)蛋白1抗體
  • 英文名稱：
    Rabbit anti-MTA1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41708R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41708R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41708R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱MTA1
中文名稱腫瘤轉(zhuǎn)移相關(guān)蛋白1抗體
別    名Metastasis-associated 1; Metastasis associated 1; Metastasis associated gene 1; Metastasis associated gene 1 protein; Metastasis associated protein; Metastasis associated protein MTA 1; Metastasis associated protein MTA1; MTA 1; MTA1_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量81kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MTA1:601-715/715 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This protein was identified in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this protein has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70 kDa component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this protein suggests that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

Function:
May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.

Subunit:
Component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). Interacts with HDAC1 and ITGB3BP/CENPR. Binds to CSNK1G2 in the cytoplasm.

Subcellular Location:
Cytoplasm and Nucleus.

Tissue Specificity:
Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual.

Similarity:
Contains 1 BAH domain. Contains 1 ELM2 domain.
Contains 1 GATA-type zinc finger.
Contains 1 SANT domain.

SWISS:
Q13330

Gene ID:
9112

Database links:

Entrez Gene: 9112 Human

Entrez Gene: 116870 Mouse

Entrez Gene: 64520 Rat

Omim: 603526 Human

SwissProt: Q13330 Human

SwissProt: Q2KHS8 Mouse

SwissProt: Q8K4B0 Mouse

SwissProt: Q62599 Rat

Unigene: 101448 Human

Unigene: 525629 Human

Unigene: 212577 Mouse

Unigene: 5840 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

轉(zhuǎn)錄調(diào)節(jié)因子（Transcriptin Regulators）
MTA1(Metastasis-associated 1)蛋白是一種蛋白復(fù)合物,它具有組蛋白脫乙酰基酶的活性,在組蛋白的脫乙酰基,染色質(zhì)重塑,轉(zhuǎn)錄控制的過程中具有重要作用。