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生長抑制DNA損傷基因45抗體
  • 產(chǎn)品貨號：
    BN41697R
  • 中文名稱：
    生長抑制DNA損傷基因45抗體
  • 英文名稱：
    Rabbit anti-GADD45A Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41697R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41697R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41697R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱GADD45A
中文名稱生長抑制DNA損傷基因45抗體
別    名Growth Arrest And DNA Damage Inducible Alpha; DNA Damage-Inducible Transcript 1 Protein; DDIT-1; GADD45; DDIT1; Growth Arrest And DNA Damage-Inducible Protein GADD45 Alpha; Growth Arrest And DNA-Damage-Inducible 45 Alpha; Growth Arrest And DNA-Damage-Inducible, Alpha; DNA Damage-Inducible Transcript-1; GA45A_HUMAN  




研究領(lǐng)域免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  細(xì)胞周期蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GADD45:65-165/165 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53 dependent and independent mechanisms.

Function:
In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.

Subunit:
Interacts with MAPK14. Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the GADD45 family.

SWISS:
P24522

Gene ID:
1647

Database links:

Entrez Gene: 1647 Human

Entrez Gene: 13197 Mouse

Entrez Gene: 25112 Rat

Omim: 126335 Human

SwissProt: P24522 Human

SwissProt: P48316 Mouse

SwissProt: P48317 Rat

Unigene: 80409 Human

Unigene: 72235 Mouse

Unigene: 10250 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GADD45α蛋白與細(xì)胞凋亡和死亡密切相關(guān),在某種程度上決定了細(xì)胞周期的進(jìn)程。