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Bcl-2同源結構域蛋白抗體
  • 產(chǎn)品貨號：
    BN41695R
  • 中文名稱：
    Bcl-2同源結構域蛋白抗體
  • 英文名稱：
    Rabbit anti-Beclin 1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41695R-50ul

    50ul

    ￥1486.00

    交叉反應：Rat,Mouse,Human(predicted:Bovine,Pig) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA

  • BN41695R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat,Mouse,Human(predicted:Bovine,Pig) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA

  • BN41695R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat,Mouse,Human(predicted:Bovine,Pig) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Beclin 1
中文名稱自噬效應蛋白Beclin 1抗體
別    名Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN.  
研究領域腫瘤  免疫學  神經(jīng)生物學  細胞凋亡  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human BECN1:201-330/450 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.

Function:
Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Subunit:
Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB. Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1.

Subcellular Location:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy.
Ubiquitinated. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes.

Similarity:
Belongs to the beclin family.

SWISS:
Q14457

Gene ID:
8678

Database links:

Entrez Gene: 8678 Human

Entrez Gene: 56208 Mouse

Entrez Gene: 114558 Rat

Omim: 604378 Human

SwissProt: Q14457 Human

SwissProt: O88597 Mouse

SwissProt: Q91XJ1 Rat

Unigene: 716464 Human

Unigene: 178947 Mouse

Unigene: 2776 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BECN1是一種分子質量為60KDa的蛋白質, 它能與細胞凋亡抑制劑Bcl-2相互作用, 減少中樞神經(jīng)系統(tǒng)的凋亡，參與PI3K復合物的組成和自噬體的形成。主要表達在胞質。抑癌基因beclin 1通過自噬作用來調節(jié)細胞生長。