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線粒體絲氨酸蛋白酶抗體
  • 產(chǎn)品貨號(hào)：
    BN41676R
  • 中文名稱：
    線粒體絲氨酸蛋白酶抗體
  • 英文名稱：
    Rabbit anti-HTRA2 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41676R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41676R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41676R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱HTRA2
中文名稱線粒體絲氨酸蛋白酶抗體
別    名HtrA2 / Omi; HTRA2; OMI; High temperature requirement protein a2; HTRA 2; HtrA like serine protease; HtrA serine peptidase 2; Omi stress regulated endoprotease; PARK 13; PARK13; Protease serine 25; PRSS 25; PRSS25; Serine protease 25; Serine protease HTRA2 mitochondrial; HtrA2; HTRA2_HUMAN; mitochondrial; Omi stress-regulated endoprotease; Serine protease HTRA2; Serine proteinase OMI; Serine protease htra2 mitochondrial precursor; Serine protease omi.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  新陳代謝  線粒體  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HtrA2:355-458/458 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008]

Function:
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Subunit:
Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce.

Subcellular Location:
Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein (Potential). Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

Tissue Specificity:
Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

DISEASE:
Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.

Similarity:
Belongs to the peptidase S1B family.
Contains 1 PDZ (DHR) domain.

SWISS:
O43464

Gene ID:
27429

Database links:

Entrez Gene: 27429 Human

Entrez Gene: 64704 Mouse

Entrez Gene: 297376 Rat

Omim: 606441 Human

SwissProt: O43464 Human

SwissProt: Q9JIY5 Mouse

Unigene: 469045 Human

Unigene: 21880 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HtrA2/Omi是一種寡聚絲氨酸蛋白酶,存在于大部分的正常組織器官中,當(dāng)細(xì)胞受到凋亡刺激時(shí),HtrA2/Omi可由線粒體膜間隙(mitochondrial intermembrane space)釋放進(jìn)入細(xì)胞質(zhì)中,導(dǎo)致出現(xiàn)大量的細(xì)胞凋亡性死亡，Omi/HtrA2 為促凋亡因子