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三磷酸腺苷結(jié)合盒亞家族G1抗體
  • 產(chǎn)品貨號：
    BN41674R
  • 中文名稱：
    三磷酸腺苷結(jié)合盒亞家族G1抗體
  • 英文名稱：
    Rabbit anti-ABCG1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41674R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41674R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41674R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱ABCG1
中文名稱三磷酸腺苷結(jié)合盒亞家族G1抗體
別    名ABC transporter 8; Abc8; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; ATP-binding cassette, sub family G WHITE member 1; homolog of Drosophila white; MGC34313; White protein homolog; White protein homolog ATP binding cassette transporter 8; ABC8; ABCG1; ABCG1_HUMAN; ATP-binding cassette sub family G member 1; WHT1; WHITE1; wht1. 




研究領(lǐng)域腫瘤  心血管  信號轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量76kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ABCG1:561-678/678 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.

Function:
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.

Subunit:
May form heterodimers with several heterologous partners of the ABCG subfamily.

Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.

Tissue Specificity:
Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

Post-translational modifications:
Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.

Similarity:
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.

SWISS:
P45844

Gene ID:
9619

Database links:

Entrez Gene: 510745 Cow

Entrez Gene: 9619 Human

Entrez Gene: 85264 Rat

Omim: 603076 Human

SwissProt: P45844 Human

Unigene: 124649 Human

Unigene: 8398 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ABCG1是ABC轉(zhuǎn)運(yùn)蛋白家族中的成員，是位于組織漿膜中的單體轉(zhuǎn)運(yùn)蛋白，多分布于肝、小腸、胎盤、脂肪和脾.主要用于脂質(zhì)/脂蛋白代謝與動脈粥樣硬化方面的研究.