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首頁(yè)>>免疫學(xué)>>一抗>>葡萄糖調(diào)節(jié)蛋白78/熱休克蛋白70蛋白5抗體
葡萄糖調(diào)節(jié)蛋白78/熱休克蛋白70蛋白5抗體
  • 產(chǎn)品貨號(hào)：
    BN41673R
  • 中文名稱(chēng)：
    葡萄糖調(diào)節(jié)蛋白78/熱休克蛋白70蛋白5抗體
  • 英文名稱(chēng)：
    Rabbit anti-GRP78 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41673R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41673R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41673R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱(chēng)GRP78
中文名稱(chēng)葡萄糖調(diào)節(jié)蛋白78/熱休克蛋白70蛋白5抗體
別    名BIP; HSPA5; GRP-78; glucose regulated protein 78; 78 kDa glucose regulated protein; BIP; Endoplasmic reticulum lumenal Ca2+ binding protein grp78; FLJ26106; Glucose Regulated Protein 78kDa; GRP 78; Heat Shock 70kDa Protein 5; HSPA 5; HSPA-5; Immunoglobulin Heavy Chain Binding Protein; MIF2; GRP78_HUMAN.  



研究領(lǐng)域腫瘤  細(xì)胞生物  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量78kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GRP78:251-360/654 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Function:
Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular Location:
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Similarity:
Belongs to the heat shock protein 70 family.

SWISS:
P11021

Gene ID:
3309

Database links:

Entrez Gene: 3309 Human

Entrez Gene: 14828 Mouse

Entrez Gene: 25617 Rat

Omim: 138120 Human

SwissProt: P11021 Human

SwissProt: P20029 Mouse

SwissProt: P06761 Rat

Unigene: 605502 Human

Unigene: 743241 Human

Unigene: 330160 Mouse

Unigene: 470180 Mouse

Unigene: 11088 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葡萄糖調(diào)節(jié)蛋白78是熱休克蛋白70家族的成員之一，又稱(chēng)：熱休克蛋白70蛋白5,作為一種分子伴侶在蛋白質(zhì)的折疊和轉(zhuǎn)運(yùn)過(guò)程及內(nèi)質(zhì)網(wǎng)應(yīng)激反應(yīng)中發(fā)揮重要作用.它在多種腫瘤組織中呈高表達(dá).