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Rho相關蛋白激酶1抗體
  • 產(chǎn)品貨號：
    BN41666R
  • 中文名稱：
    Rho相關蛋白激酶1抗體
  • 英文名稱：
    Rabbit anti-ROCK1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41666R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat(predicted:Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41666R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41666R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱MMP13
中文名稱基質(zhì)金屬蛋白酶13抗體
別    名CLG 3; CLG3; Collagenase 3; Collagenase3; MMP13; MMP 13; MMP-13; Matrix Metalloproteinase 13; MMP 13; MMP13_HUMAN.  
研究領域腫瘤  心血管  細胞生物  信號轉(zhuǎn)導  細胞骨架  細胞外基質(zhì)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
細胞定位細胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MMP13:251-350/471 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008].

Function:
Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.

Subcellular Location:
Secreted, extracellular space, extracellular matrix (Probable).

Tissue Specificity:
Seems to be specific to breast carcinomas.

DISEASE:
Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia Missouri type (SEMD-MO) [MIM:602111]. A bone disease characterized by moderate to severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood. Epimetaphyseal changes improve with age. Defects in MMP13 are the cause of metaphyseal anadysplasia type 1 (MANDP1) [MIM:602111]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia

Similarity:
Belongs to the peptidase M10A family.
Contains 4 hemopexin-like domains.

SWISS:
P45452

Gene ID:
4322

Database links:

Entrez Gene: 403763 Dog

Entrez Gene: 4322 Human

Entrez Gene: 17386 Mouse

Entrez Gene: 171052 Rat

Omim: 600108 Human

SwissProt: P45452 Human

SwissProt: P33435 Mouse

SwissProt: P23097 Rat

Unigene: 2936 Human

Unigene: 5022 Mouse

Unigene: 10997 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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