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神經(jīng)母細(xì)胞特異性轉(zhuǎn)移因子抗體
  • 產(chǎn)品貨號(hào)：
    BN41665R
  • 中文名稱：
    神經(jīng)母細(xì)胞特異性轉(zhuǎn)移因子抗體
  • 英文名稱：
    Rabbit anti-MASH1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41665R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Cow,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41665R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Cow,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41665R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Cow,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱ASCL1
中文名稱神經(jīng)母細(xì)胞特異性轉(zhuǎn)移因子抗體
別    名Achaete scute complex homolog 1; MASH1; MASH1/Achaete-scute homolog 1; Achaete scute complex homolog like 1; Achaete scute complex homologue 1; Achaete scute complex homologue like 1; Ascl 1; Ascl1; Ash 1; Ash1; Hash 1;Hash1; Mammalian achaete scute homolog 1; Mammalian achaete scute homologue 1; Mash 1; Achaete-scute homolog 1; ASCL1_HUMAN; ASH-1; hASH1; Class A basic helix-loop-helix protein 46; bHLHa46.  




研究領(lǐng)域神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Cow, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量26kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ASCL1:151-236/236 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

Function:
Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5'-CANNTG-3').

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.

Subcellular Location:
Nucleus (Probable).

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
P50553

Gene ID:
429

Database links:

Entrez Gene: 429 Human

Entrez Gene: 17172 Mouse

Entrez Gene: 64186 Rat

Omim: 100790 Human

SwissProt: P50553 Human

SwissProt: Q02067 Mouse

SwissProt: P19359 Rat

Unigene: 703025 Human

Unigene: 136217 Mouse

Unigene: 32936 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ASCL1/ASH1是一種神經(jīng)母細(xì)胞特異性轉(zhuǎn)移因子,可以促進(jìn)細(xì)胞向一定方向分化但卻抑制了最終的分化環(huán)節(jié),造成細(xì)胞停留于不成熟階段.