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富含半胱氨酸的酸性分泌蛋白抗體
  • 產(chǎn)品貨號：
    BN41660R
  • 中文名稱：
    富含半胱氨酸的酸性分泌蛋白抗體
  • 英文名稱：
    Rabbit anti-SPARC Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41660R-50ul

    50ul

    ￥1486.00

    交叉反應：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41660R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41660R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱SPARC
中文名稱富含半胱氨酸的酸性分泌蛋白抗體
別    名AA517111; Basement membrane protein 40; BM 40; BM40; Cysteine rich protein; hm:zeh0062; MGC128090; ON; Osteonectin; Secreted acidic cystein rich glycoprotein; Secreted protein acidic and rich in cysteine; Secreted protein acidic cysteine rich (osteonectin); Secreted protein acidic cysteine rich; SPRC; SPRC_HUMAN.  



研究領域腫瘤  細胞生物  信號轉(zhuǎn)導  干細胞  細胞周期蛋白  細胞骨架  細胞外基質(zhì)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
細胞定位細胞膜 細胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SPARC:101-200/303 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011].

Function:
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.

Similarity:
Belongs to the SPARC family.
Contains 1 EF-hand domain.
Contains 1 follistatin-like domain.
Contains 1 Kazal-like domain.

SWISS:
P09486

Gene ID:
6678

Database links:

Entrez Gene: 6678 Human

Omim: 182120 Human

SwissProt: P09486 Human

Unigene: 111779 Human

Unigene: 708558 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SPARC是從多方面調(diào)節(jié)細胞功能的細胞外基質(zhì)蛋白，SPARC蛋白在人組織中廣泛分布與組織重建和腫瘤有關。SPARC在多種腫瘤中呈高表達.