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髓樣分化蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41636R
  • 中文名稱：
    髓樣分化蛋白抗體
  • 英文名稱：
    Rabbit anti-MyD88 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41636R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41636R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41636R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱MyD88
中文名稱髓樣分化蛋白抗體
別    名myeloid differential protein-88; Myeloid differentiation primary response gene; MYD 88; MYD88D; Myeloid differentiation marker 88; Myeloid differentiation primary response gene 88; Myeloid differentiation primary response gene; Myeloid differentiation primary response protein MyD88; MYD 88; Myd88; MYD88_HUMAN; OTTHUMP00000161718; OTTHUMP00000208595; OTTHUMP00000209058; OTTHUMP00000209059; OTTHUMP00000209060.   




研究領(lǐng)域細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse MyD88:201-296/296 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

Function:
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Subunit:
Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1 (By similarity). Interacts with BMX, IL1RL1 and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. May interact with PIK3AP1 (By similarity). Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Ubiquitous.

DISEASE:
Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.

Similarity:
Contains 1 death domain.
Contains 1 TIR domain.

SWISS:
P22366

Gene ID:
17874

Database links:

Entrez Gene: 4615 Human

Entrez Gene: 17874 Mouse

Entrez Gene: 301059 Rat

Omim: 602170 Human

SwissProt: Q99836 Human

SwissProt: P22366 Mouse

SwissProt: Q6Y1S1 Rat

Unigene: 82116 Human

Unigene: 213003 Mouse

Unigene: 37341 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MyD88是天然免疫中的調(diào)控分子,可能在感染、炎癥、免疫等病理生理過(guò)程中具有更廣泛的生物學(xué)功能,　MyD88蛋白是由Toll樣受體介導(dǎo)的先天免疫應(yīng)答反應(yīng)中重要的胞漿接頭蛋白，由它參與構(gòu)成的信號(hào)級(jí)聯(lián)最終引起NF-kB依賴性信號(hào)通路的活化。