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骨形態(tài)發(fā)生蛋白2抗體
  • 產(chǎn)品貨號：
    BN41617R
  • 中文名稱：
    骨形態(tài)發(fā)生蛋白2抗體
  • 英文名稱：
    Rabbit anti-BMP2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41617R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41617R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41617R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱BMP2
中文名稱骨形態(tài)發(fā)生蛋白2抗體
別    名Bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2A; BMP-2; BMP2_HUMAN.  
研究領(lǐng)域細胞生物  免疫學  發(fā)育生物學  神經(jīng)生物學  生長因子和激素  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量13/44kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human BMP2:283-365/396 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis.

Function:
Induces cartilage and bone formation.

Subunit:
Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN.

Subcellular Location:
Secreted.

Tissue Specificity:
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Similarity:
Belongs to the TGF-beta family.

SWISS:
P12643

Gene ID:
650

Database links:

Entrez Gene: 650 Human

Entrez Gene: 12156 Mouse

Entrez Gene: 29373 Rat

Omim: 112261 Human

SwissProt: P12643 Human

SwissProt: P21274 Mouse

SwissProt: P49001 Rat

Unigene: 73853 Human

Unigene: 103205 Mouse

Unigene: 90931 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)干細胞標志物
BMP-2主要對未分化間充質(zhì)細胞和骨系細胞起到募集和分化作用。在骨形成早期，BMP-2不僅可使未分化間質(zhì)細胞向骨形成中心募集，并分化為骨系細胞，而且可使成纖維細胞、成肌細胞及骨髓的基細胞逆轉(zhuǎn)分化為骨系細胞。其主要過程是：增加或抑制這些細胞內(nèi)的某些特異性蛋白的分泌，使成纖維細胞分化為成骨細胞，成肌細胞快速分化為肥大的軟骨細胞，并促進基質(zhì)鈣化。
對于成骨細胞，BMP-2則可使之維持其特有細胞表型，并誘導成骨細胞標志物的增高，促進細胞外基質(zhì)鈣化。在骨形成后期，BMP-2還作為一種破骨細胞分化因子與其它支持破骨細胞分化因子直接或間接刺激破骨細胞分化，參與骨的重建。