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多巴胺受體D2抗體
  • 產(chǎn)品貨號(hào)：
    BN41615R
  • 中文名稱：
    多巴胺受體D2抗體
  • 英文名稱：
    Rabbit anti-Dopamine D2 Receptor Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41615R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41615R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41615R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Dopamine D2 Receptor
中文名稱多巴胺受體D2抗體
別    名D2DR; D2 dopamine receptor; D2R; Dopamine receptor D2; Dopamine Receptor D2L; DRD 2; DRD2; DRD2_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human DRD2:201-300/443 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Function:
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

Subcellular Location:
Cell membrane.

DISEASE:
Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P14416

Gene ID:
1813

Database links:

Entrez Gene: 1813 Human

Entrez Gene: 13489 Mouse

Entrez Gene: 24318 Rat

Omim: 126450 Human

SwissProt: P14416 Human

SwissProt: P61168 Mouse

SwissProt: P61169 Rat

Unigene: 73893 Human

Unigene: 41970 Mouse

Unigene: 87299 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

DAD2主要用于多態(tài)性與精神分裂癥方面的研究.