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細(xì)胞角蛋白4抗體
  • 產(chǎn)品貨號：
    BN41612R
  • 中文名稱：
    細(xì)胞角蛋白4抗體
  • 英文名稱：
    Rabbit anti-Cytokeratin 4 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41612R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41612R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41612R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Cytokeratin 4
中文名稱細(xì)胞角蛋白4抗體
別    名CK 4; CK4; CYK 4; CK-4; CYK4; Cytokeratin4; Cytokeratin-4; FLJ31692; K4; Keratin 4; Keratin-4; Keratin type II cytoskeletal 4; Keratin4; KRT 4; KRT4; K2C4_HUMAN; Keratin, type II cytoskeletal 4; K4; Type-II keratin Kb4.  
研究領(lǐng)域腫瘤  信號轉(zhuǎn)導(dǎo)  上皮細(xì)胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CK4:256-360/594 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Subunit:
Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13.

Tissue Specificity:
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.

DISEASE:
Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P19013

Gene ID:
3851

Database links:

Entrez Gene: 3851 Human

Omim: 123940 Human

SwissProt: P19013 Human

Unigene: 654610 Human

Unigene: 706527 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結(jié)構(gòu)蛋白（Structural Proteins）
細(xì)胞角蛋白是一類與結(jié)構(gòu)相關(guān)的蛋白家族，他們在上皮細(xì)胞中形成了細(xì)胞骨架中間絲。角蛋白在上皮細(xì)胞中往往成對存在，具有組織和細(xì)胞特異性。存在于口腔黏膜、鼻腔、食道和肛門生殖器上皮中的特異角蛋白為CK4和CK13。CK4是II型角蛋白，普遍存在于非角質(zhì)化的鱗狀上皮細(xì)胞中，CK4表達(dá)于基底細(xì)胞，也表達(dá)于鱗狀細(xì)胞癌。