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脊髓灰質炎病毒受體相關蛋白4抗體
  • 產品貨號：
    BN41609R
  • 中文名稱：
    脊髓灰質炎病毒受體相關蛋白4抗體
  • 英文名稱：
    Rabbit anti-Nectin 4 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41609R-50ul

    50ul

    ￥1486.00

    交叉反應：Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Rat) 推薦應用：WB,ELISA

  • BN41609R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Rat) 推薦應用：WB,ELISA

  • BN41609R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Rat) 推薦應用：WB,ELISA

產品描述

英文名稱Nectin 4
中文名稱脊髓灰質炎病毒受體相關蛋白4抗體
別    名Ig superfamily receptor LNIR; Nectin 4; poliovirus receptor-related 4; PRR4; poliovirus receptor related 4; DKFZp686K05193; EDSS1; Nectin-4; poliovirus receptor-related 4; Processed poliovirus receptor-related protein 4; pvrl4; PVRL4_HUMAN.  
研究領域腫瘤  細胞生物  免疫學  細菌及病毒  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53kDa
細胞定位細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Nectin 4:151-250/510 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Function:
Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4. Binds to Measles virus protein H and acts as a receptor for this virus.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, adherens junction. Processed poliovirus receptor-related protein 4: Secreted.

Tissue Specificity:
Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

Similarity:
Belongs to the nectin family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
Q96NY8

Gene ID:
81607

Database links:

Entrez Gene: 81607 Human

Entrez Gene: 71740 Mouse

Entrez Gene: 498281 Rat

Omim: 609607 Human

SwissProt: Q5E9Z9 Cow

SwissProt: Q96NY8 Human

SwissProt: Q8R007 Mouse

Unigene: 492490 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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