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瘦素受體抗體
  • 產(chǎn)品貨號：
    BN41601R
  • 中文名稱：
    瘦素受體抗體
  • 英文名稱：
    Rabbit anti-Leptin receptor Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN41601R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IF

  • BN41601R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IF

  • BN41601R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IF

產(chǎn)品描述

英文名稱Leptin receptor
中文名稱瘦素受體抗體
別    名obl; CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEPR; LEPROT; Leptin receptor fatty; Leptin receptor gene related protein; Leptin receptor precursor; OB R; OB-R; OB R gene related protein; OB receptor; OB-RGRP; Obr; Ob-R a/b/c/d/e; LEPR_HUMAN; LEPRD; Leptin receptor.  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量130kDa
細(xì)胞定位細(xì)胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Leptin receptor:501-600/1165 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

Function:
Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.

Subunit:
On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits LRb signaling.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable).

Tissue Specificity:
Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.

Post-translational modifications:
On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.

Similarity:
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 4 fibronectin type-III domains.
Contains 1 Ig-like (immunoglobulin-like) domain.

SWISS:
P48357

Gene ID:
3953

Database links:

Entrez Gene: 3953 Human

Entrez Gene: 16847 Mouse

Entrez Gene: 24536 Rat

Omim: 601007 Human

SwissProt: P48357 Human

SwissProt: P48356 Mouse

SwissProt: Q62959 Rat

Unigene: 23581 Human

Unigene: 723178 Human

Unigene: 259282 Mouse

Unigene: 9891 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Leptin是一種分子量為16kDa的脂肪組織源激素，由脂肪細(xì)胞分泌的，具有強(qiáng)親水性，以單體形式存在于血漿中。 Leptin 具有廣泛的生物學(xué)效應(yīng)，作用于下丘腦，調(diào)節(jié)食欲、能量代謝及體重。Leptin 還可能作為脂肪-胰島內(nèi)分泌軸一部分，參與胰島素分泌的調(diào)節(jié)。Leptin receptor (OB-R)是與gp130最密切相關(guān)的信號轉(zhuǎn)導(dǎo)的共同成分,屬1類細(xì)胞因子超家族，下丘腦有豐富的Leptin receptor，在其它部位也有分布，但水平較低，如：胰島素B細(xì)胞、脈絡(luò)叢、肝、肺、心、腎、睪丸、淋巴細(xì)胞和脂肪細(xì)胞中。 人類存在四個異性體，均為單跨膜受體。其中OB-Rb在胞內(nèi)結(jié)構(gòu)域最長，是唯一能進(jìn)行信號傳導(dǎo)并調(diào)節(jié)熱量攝入和能量消耗的異性體,分子量為132kDa。























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