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血管生成素-1抗體
  • 產(chǎn)品貨號(hào)：
    BN41592R
  • 中文名稱(chēng)：
    血管生成素-1抗體
  • 英文名稱(chēng)：
    Rabbit anti-Angiopoietin-1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41592R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41592R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41592R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱(chēng)Angiopoietin-1
中文名稱(chēng)血管生成素-1抗體
別    名ANG; AGP 1; AGP1; AGPT; ANG 1; ANG1; Angiopoietin1; Angiogenin; ANGPT 1; ANGPT1; ANGPT-1; Angiopoietin-1; Angiopoietin 1; ANG-1; angiopoietin-1 isoform 1 precursor; ANGP1_HUMAN.  


研究領(lǐng)域腫瘤  心血管  細(xì)胞生物  生長(zhǎng)因子和激素  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Angiopoietin 1:276-375/498 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010].

Function:
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Subunit:
Homooligomer. Interacts with TEK/TIE2.

Subcellular Location:
Secreted.

Post-translational modifications:
Glycosylated.

Similarity:
Contains 1 fibrinogen C-terminal domain.

SWISS:
Q15389

Gene ID:
284

Database links:

Entrez Gene: 284 Human

Entrez Gene: 11600 Mouse

Omim: 601667 Human

SwissProt: Q15389 Human

SwissProt: O08538 Mouse

Unigene: 369675 Human

Unigene: 309336 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Ang1/2與血管生成關(guān)系最為密切,目前有關(guān)該家族成員在腫瘤血管生成中的研究正日益增多。近年來(lái)也用于糖尿病導(dǎo)致的血管損傷研究也是熱門(mén)課題。