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纖維連接蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41572R
  • 中文名稱：
    纖維連接蛋白抗體
  • 英文名稱：
    Rabbit anti-Fibronectin/FN1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41572R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat,Cow(predicted:Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41572R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat,Cow(predicted:Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41572R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat,Cow(predicted:Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Fibronectin/FN1
中文名稱纖維連接蛋白抗體
別    名CIG; Cold insoluble globulin; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; ED B; ED-B; fibronectin 1; FINC; FN 1; FN; FN1; FNZ; GFND; GFND2; LETS; Migration stimulating factor; MSF; Transformation sensitive protein; FINC_HUMAN; Fibronectin; Cold-insoluble globulin; Ugl-Y3.  



研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞粘附分子  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Cow,  (predicted: Dog, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量259kDa
細(xì)胞定位細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Fibronectin/Ugl-Y3:1201-1300/2386 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008].

Function:
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Subunit:
Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7. Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth. Interacts with FST3.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.

Post-translational modifications:
Sulfated.
It is not known whether both or only one of Thr-2064 and Thr-2065 are/is glycosylated.
Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
Phosphorylation sites are present in the extracellular medium.
Proteolytic processing produces the C-terminal NC1 peptide, anastellin.

DISEASE:
Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.

Similarity:
Contains 12 fibronectin type-I domains. Contains 2 fibronectin type-II domains. Contains 16 fibronectin type-III domains.

SWISS:
P11276

Gene ID:
2335

Database links:

Entrez Gene: 280794 Cow

Entrez Gene: 2335 Human

Entrez Gene: 14268 Mouse

Entrez Gene: 25661 Rat

Omim: 135600 Human

SwissProt: P07589 Cow

SwissProt: P02751 Human

SwissProt: P11276 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細(xì)胞粘附蛋白（Call Adhesion Protein）
FaN（Fibronectin）是一種細(xì)胞粘附蛋白，參與細(xì)胞粘附，分化，移動(dòng)，傷口愈合，凝血和機(jī)體防衛(wèi)。主要分布于結(jié)締組織及大部分基底膜上，作為判斷良惡性上皮源性腫瘤(如乳腺癌等)的一個(gè)主要參考指標(biāo)，亦可作為惡性腫瘤轉(zhuǎn)移和病人預(yù)后的判斷指標(biāo)