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水通道蛋白4抗體
  • 產(chǎn)品貨號：
    BN41564R
  • 中文名稱：
    水通道蛋白4抗體
  • 英文名稱：
    Rabbit anti-Aquaporin 4 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41564R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt

  • BN41564R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt

  • BN41564R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Pig,Cow,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt

產(chǎn)品描述

英文名稱Aquaporin 4
中文名稱水通道蛋白4抗體
別    名aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.  


研究領(lǐng)域腫瘤  信號轉(zhuǎn)導(dǎo)  通道蛋白  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AQP4:271-323/323 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.

Subunit:
Homotetramer. Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Brain, muscle, heart, kidney, lung, and trachea.

Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.

SWISS:
P55088

Gene ID:
361

Database links:

Entrez Gene: 281008 Cow

Entrez Gene: 361 Human

Entrez Gene: 11829 Mouse

Entrez Gene: 25293 Rat

Omim: 600308 Human

SwissProt: O77750 Cow

SwissProt: P55087 Human

SwissProt: P55088 Mouse

SwissProt: P47863 Rat

Unigene: 281008 Cow

Unigene: 315369 Human

Unigene: 250786 Mouse

Unigene: 90091 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

通道蛋白（Channel Protein）
水通道蛋白(AQPs)廣泛分布于機(jī)體不同組織器官中,腦組織中的水通道蛋白主要為AQP4.
AQP-4蛋白主要在星型膠質(zhì)細(xì)胞和室管膜細(xì)胞內(nèi)表達(dá),尤其在于毛細(xì)血管和軟腦膜直接接觸的膠質(zhì)細(xì)胞上及血管周表達(dá)豐富.
水通道蛋白4的分布特點與其功能密切相關(guān),可能是腦脊液重吸收、滲透壓調(diào)節(jié)、腦水腫形成等生理、病理過程的分子生物學(xué)基礎(chǔ).研究水通道蛋白4可為腦水腫及水代謝疾病提供分子水平的理論依據(jù),同時為臨床治療腦水腫及水代謝疾病提供一種新途徑.













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