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脂聯(lián)素受體2抗體
  • 產(chǎn)品貨號：
    BN41562R
  • 中文名稱：
    脂聯(lián)素受體2抗體
  • 英文名稱：
    Rabbit anti-Adiponectin receptor 2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

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  • BN41562R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41562R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41562R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Adiponectin receptor 2
中文名稱脂聯(lián)素受體2抗體
別    名Adipo R2; Progestin and adipoQ receptor family member II; Adipor2; PAQR2; ADR2_HUMAN.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  生長因子和激素  細(xì)胞膜受體  糖尿病  內(nèi)分泌病  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Adiponectin receptor 2:315-340/386 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

Function:
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.

Subunit:
May form homo and heteromultimers.

Subcellular Location:
Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.

Tissue Specificity:
Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.

Similarity:
Belongs to the ADIPOR family.

SWISS:
Q86V24

Gene ID:
79602

Database links:

Entrez Gene: 79602 Human

Entrez Gene: 68465 Mouse

Entrez Gene: 404694 Pig

Entrez Gene: 312670 Rat

Omim: 607946 Human

SwissProt: Q86V24 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

脂聯(lián)素與受體結(jié)合后具有增強(qiáng)胰島素敏感性，抗高血糖，抗動脈粥樣硬化等生物學(xué)效應(yīng)，任何增加或減少脂聯(lián)素及其受體表達(dá)的方法都影響這些疾病的發(fā)生和發(fā)展。
脂聯(lián)素受體(AdipoR1和AdipoR2)同屬于PAQR家族，具有七次跨膜蛋白的特有結(jié)構(gòu).