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嗜鉻粒素A抗體
  • 產(chǎn)品貨號：
    BN41548R
  • 中文名稱：
    嗜鉻粒素A抗體
  • 英文名稱：
    Rabbit anti-Chromogranin A Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41548R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN41548R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN41548R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Chromogranin A
中文名稱嗜鉻粒素A抗體
別    名beta Granin; CGA; CHG A; CHGA; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; Pancreastatin; Parastatin; Parathyroid secretory protein 1; Pituitary secretory protein I; SP I; SP1; SPI; Vasostatin; ER-37; CMGA_HUMAN.   



研究領(lǐng)域腫瘤  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量48kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CGA:421-470/457 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008].

Function:
Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.

Subunit:
Interacts with SCG3.

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions.

Post-translational modifications:
Sulfated on tyrosine residues and/or contains sulfated glycans.
O-glycosylated with core 1 or possibly core 8 glycans.

Similarity:
Belongs to the chromogranin/secretogranin proteinfamily.

SWISS:
P10645

Gene ID:
1113

Database links:

Entrez Gene: 1113 Human

Entrez Gene: 12652 Mouse

Omim: 118910 Human

SwissProt: P10645 Human

SwissProt: P26339 Mouse

Unigene: 150793 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

嗜鉻粒素A蛋白存在與很多組織中：胃腸道內(nèi)分泌細(xì)胞和類癌、甲狀旁腺、垂體前葉、腎上腺髓質(zhì)、神經(jīng)節(jié)、副神經(jīng)節(jié)、胰島、甲狀腺C細(xì)胞等組織和其來源的腫瘤都表達(dá)該成分.嗜鉻素A（CgA）屬于可溶性的酸性蛋白，主要存在于神經(jīng)內(nèi)分泌細(xì)胞的分泌顆粒中，也存在于含有分泌顆粒的內(nèi)分泌細(xì)胞和神經(jīng)內(nèi)分泌細(xì)胞來源的腫瘤細(xì)胞中。檢測循環(huán)中的免疫反應(yīng)CgA對神經(jīng)內(nèi)分泌瘤具有診斷意義。另外，CgA的免疫組織化學(xué)檢測對鑒定來源于神經(jīng)內(nèi)分泌的腫瘤起到輔助作用。