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周期蛋白依賴激酶抑制因子1C抗體
  • 產(chǎn)品貨號(hào)：
    BN41547R
  • 中文名稱：
    周期蛋白依賴激酶抑制因子1C抗體
  • 英文名稱：
    Rabbit anti-p57 Kip2/Cdkn1c Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41547R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Sheep,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41547R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Sheep,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41547R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Sheep,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱p57 Kip2/Cdkn1c
中文名稱周期蛋白依賴激酶抑制因子1C抗體
別    名Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip2; p57 Kip 2; p57Kip2; WBS; IMAGE; CDN1C_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  細(xì)胞周期蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Cow, Sheep, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量35kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from rat Cdkn1c:291-343/343 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

Function:
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Subunit:
Interacts with PCNA.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

DISEASE:
Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
Defects in CDKN1C are the cause of intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE) [MIM:614732]. A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis.
Note=Defects in CDKN1C are involved in tumor formation.

Similarity:
Belongs to the CDI family.

SWISS:
E9PTV7

Gene ID:
246060

Database links:

Entrez Gene: 1028 Human

Entrez Gene: 12577 Mouse

Entrez Gene: 246060 Rat

Omim: 600856 Human

SwissProt: P49918 Human

SwissProt: P49919 Mouse

SwissProt: E9PTV7 Rat

SwissProt: Q69DC0 Rat

Unigene: 106070 Human

Unigene: 168789 Mouse

Unigene: 162507 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

p57 Kip-2調(diào)控周期蛋白依賴蛋白激酶、G1 期, 是細(xì)胞周期蛋白依賴性激酶(CDK)的抑制蛋白。它通過調(diào)控細(xì)胞周期進(jìn)程，參與腫瘤細(xì)胞的增殖、分化與凋亡。在多種腫瘤中均發(fā)現(xiàn)p57,kip2表達(dá)異常，在某些腫瘤中是一種獨(dú)立的預(yù)后因素，與腫瘤的發(fā)生、發(fā)展及預(yù)后有著密切關(guān)系。