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CD44抗體
  • 產(chǎn)品貨號(hào)：
    BN41543R
  • 中文名稱：
    CD44抗體
  • 英文名稱：
    Rabbit anti-CD44 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41543R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rabbit(predicted:Rat,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,ELISA

  • BN41543R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rabbit(predicted:Rat,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,ELISA

  • BN41543R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rabbit(predicted:Rat,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,ELISA

產(chǎn)品描述

英文名稱CD44
中文名稱CD44抗體
別    名LHR; BA-1; CD 44; CD44; CD44 antigen; CD44 molecule; CD44_HUMAN; CDw44; Cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HSA; HUTCH-I; HUTCH1; Hyaluronate receptor; MDU2; MDU3; MIC4; MUTCH1; PGP-1; PGP1; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; CD44 antigen isoform 1 precursor.  





研究領(lǐng)域腫瘤  免疫學(xué)  干細(xì)胞  細(xì)胞表面分子  糖蛋白  細(xì)胞類型標(biāo)志物  t-淋巴細(xì)胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rabbit,  (predicted: Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1μg/Test （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量85kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD44:701-742/742 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008].

Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Subunit:
Interacts with PKN2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges.

Tissue Specificity:
Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Post-translational modifications:
Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
N- and O-glycosylated. O-glycosylation contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638.
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.

Similarity:
Contains 1 Link domain.

SWISS:
P16070

Gene ID:
960

Database links:

Entrez Gene: 281057 Cow

Entrez Gene: 960 Human

Entrez Gene: 12505 Mouse

Entrez Gene: 100301546 Rabbit

Entrez Gene: 25406 Rat

Omim: 107269 Human

SwissProt: Q29423 Cow

SwissProt: P16070 Human

SwissProt: P15379 Mouse

SwissProt: P26051 Rat

Unigene: 502328 Human

Unigene: 423621 Mouse

Unigene: 1120 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD44是一個(gè)重要的細(xì)胞表面粘附分子。它在許多類型的人類細(xì)胞上都表達(dá)，在很多生理和病理過程中有復(fù)雜的作用，例如細(xì)胞遷移和在腫瘤細(xì)胞的生長調(diào)控中。CD44傳遞著諸多的細(xì)胞通路，有研究者認(rèn)為CD44是一個(gè)新的信號(hào)通路蛋白。CD44介導(dǎo)淋巴細(xì)胞與血管內(nèi)皮細(xì)胞包括粘膜組織中高內(nèi)皮小靜脈的粘連，這可能是通過激活其它粘附分子而間接造成的。CD44也是腫瘤細(xì)胞浸潤的重要因素。