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硫氧還蛋白抗體
  • 產(chǎn)品貨號：
    BN41534R
  • 中文名稱：
    硫氧還蛋白抗體
  • 英文名稱：
    Rabbit anti-Thioredoxin Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN41534R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Species independent) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41534R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Species independent) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41534R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Species independent) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Thioredoxin
中文名稱硫氧還蛋白抗體
別    名ADF; Surface associated sulphydryl protein; Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TXN protein; ADF; ATL derived factor; DKFZp686B1993; MGC61975; SASP; Surface associated sulphydryl protein; Surface-associated sulphydryl protein; Thioredoxin; TRDX; TRX 1; TRX; TRX1; TXN; TXN; ATL derived factor; ATL-derived factor; THIO_HUMAN; zgc:92903.  



研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, fusion protein)
產(chǎn)品應(yīng)用WB=1:1000-5000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Thioredoxin:51-105/105 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

Subunit:
Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.

Subcellular Location:
Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.

Similarity:
Belongs to the thioredoxin family. Contains 1 thioredoxin domain.

SWISS:
P10599

Gene ID:
7295

Database links:

Entrez Gene: 7295 Human

Entrez Gene: 22166 Mouse

Entrez Gene: 116484 Rat

Omim: 187700 Human

SwissProt: P10599 Human

SwissProt: P10639 Mouse

SwissProt: P11232 Rat

Unigene: 435136 Human

Unigene: 260618 Mouse

Unigene: 29777 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

硫氧還蛋白(Thioredoxin，Trx)是一類廣泛存在于生物體內(nèi)的多功能酸性蛋白，分子量約12kDa，是一種小分子含硒蛋白質(zhì),參與細(xì)胞的一系列生化反應(yīng)，包括酶活性的調(diào)節(jié)、轉(zhuǎn)錄因子的調(diào)控等，是重要的酶活力調(diào)節(jié)蛋白。
硫氧還蛋白的功能絕大多數(shù)是依賴于硫氧還蛋白還原靶蛋白中的二硫鍵。所有硫氧還蛋白均有一個保守的活性中心，Trp-Cys-Gly(Ala)-Pro-Cys，活性中心有兩個具有氧還活性的半胱氨酸殘基。