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髓鞘堿性蛋白/磷脂堿性蛋白抗體
  • 產(chǎn)品貨號：
    BN41529R
  • 中文名稱：
    髓鞘堿性蛋白/磷脂堿性蛋白抗體
  • 英文名稱：
    Rabbit anti-MBP Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41529R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat,GuineaPig(predicted:Pig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41529R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat,GuineaPig(predicted:Pig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41529R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat,GuineaPig(predicted:Pig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱MBP
中文名稱髓鞘堿性蛋白/磷脂堿性蛋白抗體
別    名Myelin Basic Protein; Myelin basic protien; GDB; Golli MBP; Hemopoietic MBP; HMBPR; HUGO; MBP; MGC99675; MLD; Myelin A1 Protein; Myelin Deficient; Myelin Membrane Encephalitogenic Protein; SHI; Shiverer; SP; MBP_HUMAN . 


研究領(lǐng)域神經(jīng)生物學  生長因子和激素  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Pig, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量33kDa
細胞定位細胞核 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from Gpig MBP:69-85/167 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.

Function:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

Subunit:
Homodimer. Isoform 3 exists as a homodimer.

Subcellular Location:
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.

Tissue Specificity:
MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

Post-translational modifications:
Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic.
The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).
Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.
Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.

Similarity:
Belongs to the myelin basic protein family.

SWISS:
N/A

Gene ID:
100731253

Database links:

Gene ID: 100731253 Guinea pig

Entrez Gene: 4155 Human

Entrez Gene: 17196 Mouse

Entrez Gene: 414286 Pig

Entrez Gene: 24547 Rat

Omim: 159430 Human

SwissProt: P02686 Human

SwissProt: P04370 Mouse

SwissProt: P81558 Pig

SwissProt: P25274 Rabbit

SwissProt: P02688 Rat

Unigene: 551713 Human

Unigene: 63285 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)生物學相關(guān)蛋白（Neurobiology）

少突膠質(zhì)細胞標志物
主要用于脊髓脫髓鞘病-脊髓多發(fā)硬化癥的研究。
MBP髓鞘堿性蛋白和髓鞘相伴糖蛋白是多發(fā)性硬化的自身免疫攻擊的靶。
Myelin basic protein (MPB) ：Oligodendrocyte Protein produced by mature oligodendrocytes; located in the myelin sheath surrounding neuronal structures 髓磷脂Myelin/oligodendrocyte specific protein (MOSP)是由中樞神經(jīng)系統(tǒng)中少突膠質(zhì)細胞和外周神經(jīng)系統(tǒng)中雪旺氏細胞產(chǎn)生特殊蛋白質(zhì)。是形成髓鞘的主要成分，對于引導神經(jīng)沖動的傳遞起著致關(guān)重要的作用。 多年來，關(guān)于髓鞘的形成機理和與其相關(guān)的一些先天性疾病的發(fā)病機制一直是眾多科學家關(guān)注的重點。如：多重硬化癥和腦白質(zhì)營養(yǎng)不良等，都與神經(jīng)系統(tǒng)的去髓鞘化相關(guān)。





























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